Boosting Cancer Immunotherapy by Targeting DNA Repair
In the relentless pursuit of more effective cancer treatments, a burgeoning field of research has been focusing on an intricate cellular process known as the DNA damage response (DDR). Recent…
GEN‘s 2025 Holiday Gift Guide for the Scientist on Your List
The turkey’s been eaten, the dishes are washed, and Thanksgiving is officially over; if you’re anything like me, you did not cross as much off of your shopping list as…
tRFs: New Non-Coding Suspects in Colorectal Cancer
In the relentless quest to decode the mysteries of cancer biology, a groundbreaking study has unveiled a novel layer of complexity within the tumor transcriptome of colorectal cancer, one of…
androgen receptor pathway inhibitors (ARPIs)
Cancer
Hormone-sensitive prostate cancer
multimodal therapy survival outcomes
personalized treatment intensification
PSMA PET imaging
Tailored Treatment Boost for Hormone-Sensitive Prostate Cancer
In the evolving landscape of prostate cancer treatment, hormone-sensitive prostate cancer (HSPC) has traditionally been managed with androgen-deprivation therapy (ADT) as a monotherapy. For decades, ADT was the cornerstone of…
MRI Advances in Evaluating Cervicofacial Lymphatic Malformations
In the realm of pediatric radiology, a newly published study sheds light on the pivotal role of magnetic resonance imaging (MRI) in managing cervicofacial lymphatic malformations. These intricate conditions, characterized…
Backbone Potential: Actuate’s Elraglusib Shows Promise vs. Pancreatic Cancer
Five years after Alex Trebek shared publicly his diagnosis of stage IV metastatic pancreatic cancer, therapies for the disease remain few, and limited to specific patient subgroups. Metastatic pancreatic cancer…
Predicting Melanoma Recurrence with Circulating DNA
Emerging research is shedding new light on the prognosis of melanoma, specifically focusing on the risk of recurrence in patients who have undergone surgery for stage I-III melanoma. Despite advances…
Myeloid Cells and Tregs Signal Breast Metastasis
In a significant advancement for breast cancer diagnostics, researchers have uncovered a potent predictive biomarker combination involving myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs), which may transform the…
DNA Damage Sensor Reveals Repair in Real Time
Credit: man_at_mouse/Getty Images A new fluorescent sensor is giving scientists an unprecedented view of how cells respond to DNA damage, capturing the repair process as it unfolds in real time.…
miR-770-5p Regulates KLF4/EGFR via PRMT5
In the rapidly evolving landscape of molecular oncology, a groundbreaking discovery has emerged that could redefine therapeutic strategies against several malignancies. Recent research uncovers the pivotal role of microRNA-770-5p (miR-770-5p)…